Radiation Oncology
Prof. Dr. Levent Kabasakal
1. Radiation Therapy
• External Beam Radiation Therapy (EBRT)
• Intensity-Modulated Radiation Therapy (IMRT)
• Stereotactic Radiosurgery (SRS)
• Stereotactic Body Radiation Therapy (SBRT)
• Proton Therapy
• Brachytherapy
2. Nuclear Medicine
• Positron Emission Tomography (PET)
• Single Photon Emission Computed Tomography (SPECT)
• Radioisotope Therapy
• Theranostics
3. Radiobiology
• Cellular and Molecular Effects of Radiation
• Radiation-Induced DNA Damage and Repair
4. Medical Physics
• Radiation Dosimetry
• Image-Guided Radiation Therapy (IGRT)
• Treatment Planning Systems
5. Radiation Safety
• Radiation Protection Principles
• Regulatory Compliance and Standards
6. Oncological Research
• Clinical Trials in Radiation Oncology
• Radiation-Drug Combinations
• Biomarkers for Radiation Response
Treatments of Interest:
1. Curative Treatments
• Primary Treatment for Various Cancers (e.g., prostate, head and neck, lung)
• Adjuvant Therapy (post-surgery)
• Neoadjuvant Therapy (pre-surgery)
2. Palliative Treatments
• Pain Relief for Bone Metastases
• Reduction of Tumor Size to Alleviate Symptoms
3. Advanced Techniques
• Adaptive Radiation Therapy
• Flash Radiotherapy
• Hypofractionated Radiotherapy
4. Combined Modality Therapy
• Radiation with Chemotherapy
• Radiation with Immunotherapy
Education:
• Nuclear Medicine Residency, Istanbul University Cerrahpaşa Medical Faculty (1988-1993)
• MD, Ankara University Medical Faculty (1979-1986)
Academic Appointments:
• Current Position: Professor at Istanbul University Cerrahpaşa Medical Faculty, Department of Nuclear Medicine.
• Previous Positions:
• Associate Professor at the same institution (1998-2003)
• Researcher at Medical College of Wisconsin, Milwaukee, USA (1994-1995)
• Observer at Paris University, St. Antoine Hospital and Gustave Roussy Institute, Paris, France (1990)
1. Ekici H, Sontas BH, Toydemir TS, Senmevsim O, Kabasakal L, Imre Y. The effect of prepubertal ovariohysterectomy on spine 1 mineral density and mineral content in puppies: A preliminary study.Res Vet Sci. 2007 Feb;82(1):105-109.
2. Balcı, TA, Kabasakal L. Is I-131 scanning proper for the follow-up management of the patients with malignant struma ovarii without performing the thyroidectomy?. Gyneacol Oncol, 2005
3. Ahmed ASM, Demir M, Kabasakal L, Uslu İ. A dynamic phantom for nuclear medicine studies. Med Phys 2005;32:530-538
4. Massardo T, Alonso O, Llamas-Ollier A, Kabasakal L, Ravishankar U, Morales R, Delgado L, Padhy AK. Planar Tc99m--sestamibi scintimammography should be considered cautiously in the axillary evaluation of breast cancer protocols: results of an international multicenter trial. BMC Nucl Med. 2005 Jul 27;5:4.
5. Ekici H, Sontas BH, Toydemir TS, Senmevsim O, Kabasakal L, Imre Y.Effect of prepubertal ovariohysterectomy on bone mineral density and bone mineral content in puppies. Acta Vet Hung. 2005;53(4):469-78.
6. Kabasakal L,Selçuk NA, Shaffipour H, Ozmen O, Onsel Ç, Uslu İ Treatment of iodine negative thyroglobulin positive thyroid cancer: differences in outcome in patients with macrometastases and patients with micrometastases. Eur J Nucl Med Mol Imaging. 2004..
7. Kabasakal L. Treatment of iodine negative thyroglobuline positive thyroid cancer patients: Do we miss the target when we shot in the dark? Nucl Med Commun; 2003: (in press)
8. Fettich J, Colarinha P, Fischer S, Frokier J, Gordon I, Hahn K, Kabasakal L, Mann M, Mitjavila M, Olivier P, Piepsz A, Porn U, Sixt R, Van Velzen J. Guidelines for direct radionuclide cystography in children, Eur J Nucl Med Mol Imaging, 2003;30:
9. Olivier P, Colarinha P, Fettich J, Fischer S, Frokier J, Giammarile F, Gordon I, Hahn K, Kabasakal L, Mann M, Mitjavila M, Piepsz A, Porn U, Sixt R, Van Velzen J. Guidelines for radioiodinated MIBG scintigraphy in children, Eur J Nucl Med Mol Imaging, 2003;30:
10. Kabasakal L, Turkmen C, Özmen Ö, Alan N, Onsel Ç, Uslu I. Is furosemide administration effective in improving the accuracy of determination of differential renal function by means of technetium-99m DMSA in patients with hydronephrosis? Eur J Nucl Med Mol Imaging. 2002;29: 1433-1437.
11. Demir M, Konukoğlu D, Kabasakal L, Yelke HK, Ergen K, Ahmed S. The effect of exposure of Co-60 on the oxidant/antioxidant status among radiation victims. J Env Rad, 2003; 64:19-25. ( 9 puan)
12. Massordo T, Alonso O, Kabasakal L, Llamas-Olier A, Shankar UR, Zhu H, Delgado L, Gonzales P, Mut F, Padhy AK. Diagnostic value of Tc-99m methylene diphosphonate and Tc-99m pentavalent DMSA compared with Tc-99m sestamibi for palpable breast lesions. J Nucl Med, 2002;43:882-888.
13. Alonso O, Massardo T, Delgado LB, Horwvath J, Kabasakal L, Llamas OA, Maunda KK, Padhy AK, Shankar UR. Is (99m)Tc-sestamibi scintimammography complementary to conventional mammography for detecting breast cancer in patients with palpable masses? J Nucl Med. 2001 Nov;42(11):1614-21.
14. Gordon I, Colarinha P, Fettich J, Ficher S, Frokier J, Hahn K, Kabasakal L, Mitjavilla M, Olivier P, Piepsz A, Porn U, Sixt R, Velzen J. Guidelines for indirect radionuclide cystography. Eur J Nucl Med;28: BP16-20.
15. Gordon I, Colarinha P, Fettich J, Ficher S, Frokier J, Hahn K, Kabasakal L, Mitjavilla M, Olivier P, Piepsz A, Porn U, Sixt R, Velzen J. Guidelines for standard and diuretic renogram in children. Eur J Nucl Med;28: BP21-30.
16. Doğruca Z, Kabasakal L, Yapar F, Nişli C, Vural AV, Onsel Ç. A comparison of Tl-201 stress-reinjection-prone SPECT and Tc-99m-sestamibi gated SPECT in the differentiation of inferior wall defects from artifacts. Nucl Med Commun. 2000 Aug;21(8):719-27
17. Erdil TY, Onsel Ç, Kanmaz B, Caner B, Sonmezoglu K, Ciftci I, Turoğlu T, Kabasakal L, Sayman HB, Uslu I. Comparison of 99m Tc-methoxyisobutyl isonitrile and Tl-201 scintigraphy in visualization of suppressed thyroid tissue. Journal of Nuclear Medicine, 2000;41: 1163-1167. (3 puan)
18. Erdil TY, Ozker K, Kabasakal L, Kanmaz B, Sonmezoğlu K, Atasoy KC, Turoğlu HT, Uslu I, Isitman AT, Onsel Ç. Correlation of Tc-99m MIBI and Tl-201 retention in solitary cold thyrois nodules with postoperative histopathology. European Journal of Nuclear Medicine. 2000; 27: 713-720. (3 puan)
19. Yeni SN, Kabasakal L, Yalçınkaya C, Nişli C, Dervent A. Ictal and interictal SPECT findings in childhood absence epilepsy. Seizure. 2000;9: 265-269. (18 puan)
20. Kanmaz B, Erdil TY, Yardi OF, Sayman HB, Kabasakal L, Sonmezoglu K, Onsel Ç. Duren M, Nişli C, Ozcan K, Uslu İ. The role of Tc-99m tetrofosmin in the evaluation of thyroid nodules. Nuclear Medicine Communications. 2000; 21: 333-339. (1.8 puan)
21. L. Kabasakal. Technetium-99m ethylene dicysteine: a new renal tubular function agent. European Journal of Nuclear Medicine, 2000;27:351-357. (30+3=33 puan)
22. Kabasakal L, M. Kalaç, C. Nişli, O. Oğuz, Ç. Önsel, G. Çivi, İ. Uslu. The effect of P-glycoprotein function inhibition with cyclosporin-A on biodistribution of Technetium-99m sestamibi. Clinical Nuclear Medicine, 2000;25:20-23. (12+3=15 puan)
23. K. Özker, B.D. Collier, D.J. Lindner, L. Kabasakal, Y. Liu, A.Z. Krasnow, R.S. Hellman, S.D. Edwards, C.R. Bourque, P.D. Crane. Biodistribution of Tc-99m labelled 5-thio-d-glucose. Nuclear Medicine Communications, 1999;20: 1055-1058. (2 puan)
24. L. Kabasakal, M. Halaç, E. Alkan, N. Özçelik, Ç. Önsel, İ. Uslu. Reproducibility of Tc-99m EC Clearance. European Journal of Nuclear Medicine 1999;26:900-902. (12+3=15 puan)
25. L. Kabasakal, M. Halaç, A.F. Yapar, E. Alkan, B. Kanmaz, Ç: Önsel, K. Sönmezoğlu, M. Ayaz, B. Kalender, H.B. Sayman, İ. Uslu. Prospective validation of single plasma sample Tc-99m EC clearance in adults. Journal of Nuclear Medicine 1999;40:429-431. (12+3=15 puan)
26. K. Sönmezoğlu, T.Y. Erdil, M. Demir, H.B. Sayman, L. Kabasakal, ÖF. Yardı, H. Özkara, M.C. Mat, K. Solanki, K.E. Britton. Evaluation of renal function in low-dose cyclosporine-treated patients using Tc-99 m diaminocyclohexane: a cationic tubular excretion agent. European Journal of Nuclear Medicine;1998:25: 1630-1636. (3.6 puan)
27. L. Kabasakal, T.Y. Erdil, M. Ayaz, S. Atay, K. Sönmezoğlu, B. Kanmaz, U. Ülkü, İ. Uslu, H.B. Sayman, Ç. Önsel. Evaluation of Tc-99m-EC in anuric hemodialysis patients. Indian Journal of Nuclear Medicine 1998;13: 42-44. (8 puan)
28. L. Kabasakal, A.F. Yapar, K. Özker, E. Alkan, S. Atay, N. Özçelik, Ç. Önsel. Simplified Technetium-99m-EC clearance in adults from a single plasma sample. Journal of Nuclear Medicine 1997;38:1784-1786. (12+3=15 puan)
29. K. Özker, L. Kabasakal, Y. Liu, R.S. Hellman, A. Işıtman, A.Z. Krasnow, B.D. Collier. Evaluation of Tc-99m-bicisate as a renal imaging. Nuclear Medicine Communucations 1997;18:771-775. (3 puan)
30. L. Kabasakal, Ç. Önsel. Simplified determination of technetium-99m ethylenedicysteine clearance from a single plasma sample: what is the upper normal range? European Journal of Nuclear Medicine 1996;23:1556-1557. (6 puan)
31. L. Kabasakal, B.D. Collier, R. Shaker, R.S. Hellman, S. Smart, K. Özker, A.Z. Krasnow, A.T. Işıtman. Enterogastric bile reflux during technetium-99m-sestamibi cardiac imaging. Journal of Nuclear Medicine 1996;37:1285-1288. (12 puan)
32. M. Demir, L. Kabasakal, Ç. Önsel. Evaluation of radiation exposition rate from radioiodine treated hyperthyroid patients and radiation safety considerations. Nuclear Medicine Communications 1996;17:692-695 (9+3=12 puan)
33. L. Kabasakal, K. Özker, M. Hayward, G. Akansel, O. Griffith, A.T. Işıtman, R. Hellman, D. Collier. Tc-99m-setamibi uptake in human breast carcinoma cell lines displaying glutathione associated drug resistance.European Journal of Nuclear Medicine 1996;23:568-570. (12+3=15 puan)
34. L. Kabasakal, S. Atay, V.A. Vural, K. Özker, K. Sönmezoğlu, İ. Uslu, A.T. Işıtman, Ç. Önsel. Evaluation of technetium-99m-ethylenedicysteine in renal disorders and determination of extraction ratio. Journal of Nuclear Medicine 1995;36:1398-1402. (12+3=15 puan)
35. L. Kabasakal, K. Devranoğlu, O. Arslan, T.Y. Erdil, K. Sönmezoğlu, İ. Uslu, H. Tolun, A.T. Işıtman, K. Özker, Ç. Önsel. Brain SPECT evaluation of the visual cortex in amblyopia. Journal of Nuclear Medicine 1995;36:1170-1174. (12+3=15 puan)
36. L. Kabasakal, H.T. Turoğlu, Ç. Önsel, K. Özker, İ. Uslu, S. Atay, T. Cansız, K. Sönmezoğlu, E. Altıok, A.T. Işıtman, T. Kapıcıoğlu, İ. Urgancıoğlu. Clinical comparison of technetium-99m-EC, technetium-99m-MAG3 and iodine-131-OIH in renal disorders. Journal of Nuclear Medicine 1995;36:224-228. (12+3=15 puan)
37. L. Kabasakal, K. Özker, A.T. Işıtman, Ç. Önsel. Relationship between the OIH and Tc-99m-EC clearances. Nuclear Medicine Communications 1994;15:1006-1007. (4 puan)
38. K. Özker, Ç. Önsel, L. Kabasakal, H.B. Sayman, İ. Uslu, Ş. Bozluolcay, T. Cansız, T. Kapıcıoğlu, İ. Urgancıoğlu. Technetium-99m-N,N-ethylenedicysteine-A comparative study of renal scintigraphy with Tc-99m-MAG3 and iodine-131-OIH in patients with obstructive renal disease. Journal of Nuclear Medicine 1994;35:840-845. (2.25+3=5.25 puan)
39. Kabasakal L. Rekombinan TSH ve redifferansiyasyon tedavisinin iyi diffransiye tiroid kanserlerinde yeri. Türkiye Klinikleri, 2003; Nisan (Baskıda) (15 puan)
40. Dumlu A, Demir M, Kabasakal L, Özbayrak S. I-131'in oral mukoza ve tükürük bezlerine erken dönemde etkisinin klinik ve deneysel olarak incelenmesi. Turk J Nucl Med: 2001; 10: 137-143. (6 puan)
41. Yüksel D, Argon M, Atasever T, Çelen YZ, Kabasakal L, Karayalçın B, Kır M, Özdoğan Ö, Özkılıç H, Sarı O, Türkmen C, Varoğlu E, Yapar AF, Yüksel M. Diferansiye tiroid kanserlerinde radyoaktif iyot (I-131) ablasyonu ve tedavisi uygulama klavuzu. Turk J Nucl Med, 2001;10: S-23-S27. (9 puan)
42. Özdoğan Ö, Argon M, Atasever T, Çelen YZ, Kabasakal L, Karayalçın B, Kır M, Özkılıç H, Sarı O, Türkmen C, Varoğlu E, Yapar AF, Yüksel M, Yüksel Ö. I-131 ile hipertiroidizm tedavisi uygulama klavuzu. Turk J Nucl Med, 2001;10:2-29-S32 (9 puan)
43. Varoğlu E, Bayraktar R, Argon M, Atasever T, Çelen YZ, Kabasakal L, Karayalçın B, Kır M, Özdoğan Ö, Özkılıç H, Sarı O, Türkmen C, Yapar AF, Yüksel M, Yüksel D. Paratiroid sintigrafisi uygulama klavuzu. Turk J Nucl Med, 2001; 10: S33-s39. (9 puan)
44. Erbaş B, Sayman H, Alan N, Dirlik A, Ergün E, Güngör F, Kabasakal L, Kıratlı P, Özcan Z, Özmen Ö, Türkmen C. Diüretikli dinamik böbrek sintigrafisi klavuzu. Turk J Nucl Med, 2001;10: s57-s62. (2.25 puan))
45. Özmen Ö, Alan N, Kabasakal L, Dirlik A, Erbaş B, Ergün E, Güngör F, Kıratlı P, Özcan Z, Sayman H, Türkmen C. Glomerüler filtrasyon hızı ölçüm klavuzu. Turk J Nucl Med, 2001;10: s63-s69. (2.25 puan)
46. Ergün E, Erbaş B, Alan N, Dirlik A, Güngör F, Kabasakal L, Kıratlı P, Özcan Z, Özmen Ö, Sayman H, Türkmen C. Kaptoprilli böbrek sintigrafisi. Turk J Nucl Med, 2001;10: s71-s77. (2.25 puan)
47. Erbaş B, Ergün E, Alan N, Dirlik A, Güngör F, Kabasakal L, Kıratlı P, Özcan Z, Özmen Ö, Sayman H, Türkmen C. Tübüler radyofarmasötiklerin klirensinin tek kan örneği metodu ile hesaplanması için klavuz. Turk J Nucl Med, 2001;10: s78-s83. (2.25)
48. Erbaş B, Sayman H, Alan N, Dirlik A, Ergün E, Güngör F, Kabasakal L, Kıratlı P, Özcan Z, Özmen Ö, Türkmen C. Dinamik böbrek sintigrafisi klavuzu. Turk J Nucl Med, 2001;10: s85-s91. (2.25 puan)
49. Dirlik A, Erbaş B, Alan N, Ergün E, Güngör F, Kabasakal L, Kıratlı P, Özcan Z, Özmen Ö, Sayman H, Türkmen C. Transplant böbrek sintigrafisi klavuzu. Turk J Nucl Med, 2001;10:s91-s96. (2.25 puan)
50. Özcan Z, Gökçora N, Alan N, Arslan N, Erselcan T, Güngör F, Kıratlı P, Kabasakal L. Çocuklarda kemik sintigrafisi klavuzu. Turk J Nucl Med, 2001;10: s133-s137. (6 puan)
51. Özcan Z, Gökçora N, Alan N, Güngör F, Kıratlı P, Kabasakal L, Arslan N, Erselcan T. Çocuklarda MIBG sintigrafisi klavuzu. Turk J Nucl Med, 2001;10: s-139-s142. (6 puan)
52. Arslan N., Gökçora N.,Alan N.,Erselcan T.,Güngör F.,Kıratlı P., Kabasakal L.,Özcan Z. Gastroözofageal reflü(GÖR) ve pulmoner aspirasyon çalışması.Turk J.Nucl.Med.,2001;10:s143-s145. (6 puan)
53. Özcan Z., Gökçora N.,Alan N.,Erselcan T.,Güngör F.,Kıratlı P.,Kabasakal L., Pediatrik onkolojide galyum-67 sintigrafisi kılavuzu. Turk J.Nucl.Med.,2001;10:s147-s151. (6 puan)
54. Güngör F.,Gökçora N.,Alan N.,Dirlik A.,Erbaş B.,Ergün E.,Kabasakal L.,Kıratlı P.,Özcan Z.,Özmen Ö.,Sayman H.,Türkmen C. Çocuklarda standart ve diüretik dinamik renal sintigrafi protokolu. Turk J.Nucl.Med.,2001;10:sf153-s159 (2.25 puan)
55. .,Kıratlı P,Gökçora N.,Alan N.,Dirlik A.,Erbaş B.,Ergün E., Güngör F ,Kabasakal L.,.,Özcan Z.,Özmen Ö.,Sayman H.,Türkmen C. Çocuklarda radyonüklid sistografi kılavuzu. Turk J.Nucl.Med.,2001;10:sf161-s165 (2.25 puan)
56. .,Kıratlı P,Gökçora N.,Alan N.,Dirlik A.,Erbaş B.,Ergün E., Güngör F ,Kabasakal L.,.,Özcan Z.,Özmen Ö.,Sayman H.,Türkmen C. Çocuklarda kortikal sintigrafi kılavuzu. Turk J.Nucl.Med.,2001;10:sf167-s170 (2.25 puan)
57. K. Özker, Ç. Önsel, İ. Uslu, T. Turoğlu, B. Kanmaz, İ. Hacıömeroğlu, L. Kabasakal, N. Kahraman, T. Kapıcıoğlu, F. Çullu, O. F. Şenyüz, İ Urgancıoğlu. Tc-99m transrectal portal scintigraphy (TPS): A non-invasive technique for the assessment of portal hypertension. IAEA NMS-2 Vienna 1994;173-181.
58. Z. Yapar, L. Kabasakal, A. F. Yapar, V. A. Vural, Ç. Önsel. The value of gated Tc-99m-sestamibi SPECT in separation of inferior wall artifacts from infarction. Turkish Journal of Nuclear Medicine, 1999;8: 197-206. (3 puan)
59. D. Konukoğlu, M. Demir, G. K. Demiriz, L. Kabasakal, H. Hatemi. The effect of radioiodine treatment on plasma peroxides and vitamin E level in thyroidectomized patients. Turkish Journal of Nuclear Medicine, 1999;8: 103-107. (6 puan)
60. F. Erdoğan, M. Orak, Ş. Aktaş, E. Türeci, V. Olgaç, L. Kabasakal, Ö. Aydıngöz. Hiperbarik oksijen uygulamasının farelerde otoklavize otojen kemik greftinin inkorporasyonu üzerine etkisi. Acta Orthopaedica et Traumatologica Turcica 1998;32:226-231. (15 puan)
61. M. Kibar, Z. Doğruca, L. Kabasakal, G. Büyükdereli, A. Usal, M. Şan, Ç. Önsel. Gated technetium-99m-tetrofosmin SPECT in differantiation artifact from infarct. Turkish Journal of Nuclear Medicine 1997;6:153-161. (9 puan)
62. M. Kibar, Z. Doğruca, L. Kabasakal, G. Büyükdereli, A. Usal, Ç. Önsel. Tc-99m-tetrofosmin myocardial SPECT imaging in the evaluation of coronary artery disease. Turkish Journal of Nuclear Medicine 1997;6:166-173. (9 puan)
63. Ö. Aydıngöz, F. Erdoğan, L. Kabasakal, N. Karadeniz, M. Ök, E. Yentür, T. Centel. Ekstremite ameliyatlarında turnike açma zamanının postoperatif hematom oluşumuna etkisi (Deneysel çalışma). Acta Orthopaedica et Traumatologica Turcica, 1997;31:255-261. (15 puan)
64. M. Demir, S. Günebakan, C. Mete, A.F. Yapar, L. Kabasakal, B. Yurttaş, Ç. Önsel. Hipertiroidili hastalarda tedavi öncesi ve sonrası çinko düzeyi ölçümleri. Endokrinolojide Yönelişler, 1996;5:85-87.
65. Z. Doğruca, A. F. Yapar, L. Kabasakal, V.A. Yapar, Ç. Önsel, N. Erdoğan, C. Nişli. Koroner arter hastalığında Tl-201 ve Tc-99m sestamibi SPECT nükleer tıp yöntemlerinin karşılaştırılması; Anjiografi ile korrelasyon. Ç. Ü. Tıp Fakültesi Dergisi, 1996;21:210-216.
66. M. Faik Özçelik, Salih Pekmezci, Levent Kabasakal, Tülay Cansız, Kutlan Özker. Mekanik ikterde retiküloendoteliyal sistem fonksiyonları. Ulusal Cerrahi Dergisi, 1993;9:86-91.
67. M. Faik Özçelik, Salih Pekmezci, Recep Özgültekin, Levent Kabasakal, Tülay Cansız, Kutlan Özker. Mekanik ikterde internal biliyer drenajın retiküloendoteliyal sistem fonksiyonuna etkisi. Klinik ve Deneysel Cerrahi Dergisi, 1993;1:90-92.
68. D. T. Sözüer, K. Sönmezoğlu, A. Yüksel, T.Y. Erdil, İ. Uslu, Ç. Önsel, L. Kabasakal, E. Yalçın, İ. Urgancıoğlu. Brain SPECT in children with partial epilepsy: A comparison of interictal EEG, MRI, and SPECT. Medical Bulletin of İstanbul Medical Faculty, 1993;26:64-69.
69. K. Sönmezoğlu, Ç. Önsel, N. Karaağaç, L. Kabasakal, D. Sözüer, T. Y. Erdil, İ. Uslu, İ. Urgancıoğlu. Parsiyel epilepsili hastaların değerlendirilmesinde teknesyum (Tc) 99m-HMPAO beyin SPECT sintigrafisinin değeri. Klinik Gelişim, 1993;6: